The cost of clotrimazole troches in the prophylactic doses given in this study was approximately one tenth that of nystatin oral suspension. This medication may be prescribed for other uses ask your doctor or pharmacist for more information. If you stop using nystatin too soon or skip doses, your infection may not be completely treated. Reasons given for withdrawal were the unpleasant taste of the drugs, or an inability to comply with the protocol. Use nystatin as long as instructed by your doctor, even if you feel better. One patient chose to withdraw from the clotrimazole group, and eight patients withdrew from the nystatin group before completing 60 days of therapy ( P =.002). Adverse effects were infrequently seen in either group (one case of mild nausea in the clotrimazole group and three cases in the nystatin group). Both regimens were 100% effective in preventing the development of thrush in the patients studied. The two groups were comparable in age, sex, type of transplant, and amount of immunosuppression. Sixty assessable patients were randomized to receive either clotrimazole troches (n = 32) or nystatin oral suspension (n = 28) for a 60-day period after receiving a renal allograft. This study was performed as the troche form of clotrimazole was easier to administer and less costly than nystatin oral suspension. An open study designed to compare the effectiveness and safety of clotrimazole troches with nystatin oral suspension in the prevention of oropharyngeal candidiasis was conducted.
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